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6.3 SIRT6 and SIRT7 SIRT6 and SIRT7 significantly influence cardiovascular diseases by regulating several pathways (Table 4)
This indicates that the peptides can also act as transcriptional transregulators

Chen S, Du Y, Xu B, Li Q, Yang L, Jiang Z, et al

Prevention of aflatoxin B1 hepatoxicity by dietary selenium is associated with inhibition of cytochrome P450 isozymes and up-regulation of 6 selenoprotein genes in chick liver

Natural does not necessarily mean safe
