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Consequently, the global aging of the population is expected to increase the incidence and prevalence of NDs, presenting a major challenge for healthcare systems worldwide (Pichet Binette et al., 2020

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However, this outcome depends on various factors, including the availability of the substrate and whether the ROS generated by these enzymes surpass the antioxidant defense mechanisms [Frijhoff et al ., 2015]

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Unfortunately, the focus subsequently became the redox potential itself as opposed to the chemical species responsible for the negative ORP