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26 In GHD and TS, the proportion of genes potentially directly regulated by GH through STAT5 was similar (18.2% and 18.3%, respectively)

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Professor Giovanna Traina from the University of Perugia explained via email to GMFH editors that a healthy intestinal barrier is essential for the maintenance of gastrointestinal health, but also for the systemic health of the host, as it is able to preserve the potential translocation of bacteria, food allergens, xenobiotics and inflammatory mediators in the systemic circulation, that may compromise the functionality of other organs. Such a defect in the gut barrier may facilitate dietary and microbial antigen influx, leading to the chronic inflammation involved in the onset of modern diseases

93 Furthermore, PEA exhibits sensitivity to serine proteases, commonly found in inflammatory environments, making it suitable for DDS in OA treatment