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In fact, some studies have used much higher doses for short periods without observing serious adverse effects

Inhibition or knockdown of ALOX12 may be a new approach to interrupt ferroptosis (Ou et al., 2016)
The BEATRICE study was an open-label, randomized, phase III clinical trial that assessed the addition of bevacizumab to chemotherapy in adjuvant settings in patients with operable TNBC (Miller et al., 2018)

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