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The novel peptide neuropeptide W (NPW), which has 23 (NPW23) or 30 (NPW30) amino acid residues, was proposed as a mediator in controlling the neuroendocrine response to stress, because stress induction stimulates NPW-containing hypothalamic neurons and central administration of NPW in rats activates the hypothalamus-pituitary adrenal (HPA) axis (Niimi and Murao 2005)

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