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Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis

The clinical methodology was appropriate for an obesity drug: randomized, double-blind, placebo-controlled, multicenter designs with body-weight and body-composition endpoints, supported by dedicated safety, tolerability, and pharmacokinetic studies

Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Lebers disease A current infection If youre taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections

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Liver damage B complex also contains niacin (vitamin B3)