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For this reason, contraception is recommended during active GLP-1 therapy, and conception should be planned only after discontinuation and adequate washout time

Moreover, strong evidence documented the Tirze potentiality in counteracting abnormal IR responses through activation of PI3K/Akt with a sequel of suppression of GSk3- in different tissues, including the heart [35,36,37]

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Overview of established risk factors for cardiovascular disease

And, it was recently FDA approved to reduce the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and obesity or overweight