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Skov, J

Specifically in colon cancer and prostate cancer, exendin-4 increased intracellular cAMP levels while inhibiting glycogen synthase kinase 3 and ERK-MAPK activation, leading to an increase in apoptosis [93]

Other than the gastrointestinal side effects [11], tirzepatide may rarely contribute to sinus tachycardia, acute kidney injury secondary to dehydration, pancreatitis, cholelithiasis, and cholecystitis

The FDA has approved certain medications (Victoza, Ozempic, Trulicity) for cardiovascular risk reduction in patients with established cardiovascular disease and type 2 diabetes, and Wegovy for cardiovascular risk reduction in adults with established cardiovascular disease who have overweight or obesity