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To ensure the robustness of our MR findings, we conducted a series of sensitivity analyses designed to comprehensively assess the underlying MR assumptions

studies provide compelling evidence that semaglutide use in orthopedic surgery is associated with lower rates of infection, readmission, and revision surgery, likely due to improved metabolic control, reductions in systemic inflammation, and weight loss-driven perioperative risk reduction

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This highlights that many quitters become discouraged by the additional body weight, which can undermine their satisfaction with quitting