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The triple receptor activity of retatrutide, targeting GLP-1, GIP, and glucagon receptors simultaneously, also contributes to sustained metabolic effects beyond what the half-life alone would predict

Recent statistics indicate that the adherence rates with weekly GLP-1 injections are at 65-70% at 12 months and that monthly injections are in development with high adherence rates of over 85% in the clinical trials

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Gastrointestinal side effects represent the most common adverse effects of GLP-1 receptor agonists, including nausea, vomiting, diarrhoea, and constipation