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Participants taking bofanglutide experienced weight loss and improvements in various cardiometabolic risk factors
doi: 10.1056/NEJMoa1603827 11 MarsoSPBainSCConsoliAEliaschewitzFGJdarELeiterLAet al
10.1016/s0140-6736(19)31271-1 64 RamracheyaR.ChapmanC.ChibalinaM.DouH.MirandaC.GonzlezA.et al (2018)
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However, GPR43 activation by increased SCFAs increased the number of the PYY-producing cells and PYY expression, which might be an effective therapeutic target for obesity but not T2D (69)
