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Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes

Ozempic, Wegovy, Mounjaro, and Zepbound are the brand names patients hear most often, and the confusion among them is constant

Therefore, if and how GLP-1 RAs should be discontinued before surgery is a matter of debate

GLP-1 medications create a series of events: Your pancreas releases more insulin Glucagon (what triggers blood sugar release) is blocked Gastric emptying slows down (so you feel full longer) When you feel satisfied, youre less likely to overeat, and you may find it easier to stick with your daily calorie budget

Notably, we recently demonstrated that HITI outperforms HDR in terms of knock-in efficacy for GFP gene at the Alb locus in mouse hepatocyte when using clinically relevant, lipid nanoparticle (LNP)-based deliver systems