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FDA approval and regulation of pharmaceuticals, 1983-2018

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Be patient during the first few months of dose titration

almost 99% of tirzepatide patients remain free of T2D These data are reassuring for prescribers around long-term benefits and side effects of tirzepatide GIP and GLP-1 on the same backbone seem to work better than a mono agonist This is a 3-year study the longest-term duration for a dual agonist. - Sean Wharton You are going to get GI side effects everybody needs to know what is going to happen, that expectation is a really big part - Sean Wharton SURMOUNT-1: Managing Medication Side Effects Key takeaways GI side effects are common with GLP-1RA, as they target an endogenous hormone that is produced naturally after food intake to increase feelings of fullness Injecting exogenous, additional GLP-1 heightens these feelings and prevents overeating but it can also cause nausea and GI side effects But these side effects are mitigated over time on these agents