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Description
Hormonal Mechanisms and Clinical Evidence Menstrual changes on GLP-1 therapy involve multiple pathways: estrogen redistribution from fat loss, improved insulin signaling, reduced inflammation, and acute energy-deficit stress

The afferent nerves of the spinal cord receive information from the viscera through sensory endings in organ walls

GLP-1 is also an incretin hormone, enhancing insulin and suppressing glucagon secretion in the pancreas, thus lowering blood glucose
Direct cartilage benefits and weight-related joint offloading are real and clinically significant

Even during this titration period, injections remain on a once-weekly schedule unless otherwise directed
