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Animal studies provide important evidence that exercise can help mitigate bone loss associated with energy restriction or weight loss in obesity

Optimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes

They didn't get the support to help them learn how to live in a way [00:58:00] that supports their body best

Further research is however needed to elucidate the long-term impact of GLP-1RAs on skeletal muscle and to optimize interventions that preserve muscle mass while retaining metabolic benefits

And there can be very real negative side effectsnausea, fatigue, dizziness, muscle and hair lossand some people have even reported increased depression and suicidal ideation, although a large-scale meta study seemed to show no direct link to the medication itself