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In placebo-controlled trials of patients with type 1 diabetes mellitus, the risk of ketoacidosis was markedly increased in patients who received sodium glucose co-transporter 2 (SGLT2) inhibitors compared to patients who received placebo and fatal ketoacidosis has occurred with JARDIANCE

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Results Development of the secreted Exe4 peptide-coding gene To develop a one-shot in vivo genome editing-based therapy for DIO and pre-diabetes, we targeted the liver due to its large size and ease of transduction, anticipating effective therapeutic peptide/protein production and secretion following successful genome editing (Fig

Additionally, insulin, blood glucose level and body mass index (BMI) were measured as secondary outcomes (Figure 5, Figure 6, Figure 7)