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It has been found that patients with chronic malabsorption and selective IgA deficiency, who are deficient in vitamin E and selenium, develop PM when treated with iron dextran, which is believed to be related to lipid peroxidation induced by free radicals activated by free iron [235]
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Users who began protocols in their forties or fifties and continued cycling for years describe maintaining physical and cognitive function that their peers have lost

These findings support the theory that high-fat diets (potentially causing insulin resistance and T2DM) hinder mitochondrial biogenesis, which could clarify the development of anomalous myocardial performance in cases of obesity, insulin resistance, and fully developed diabetes [153]
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