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TB-500 demonstrates remarkably benign short-term side effects
In the liver, glutathione S-transferase enzymes conjugate GSH to reactive metabolites and toxins, making them water-soluble for excretion a process central to Phase II detoxification
In vitro studies have also indicated that riboflavin itself has an antioxidant nature, independent of its action as the GR coenzyme ( Reference Toyosaki and Mineshita 47 )
Similarly, although fluorescent probes targeting ACSL4a key regulator of secondary ferroptosis in TBIachieve specific labeling in vitro , they leak out of injured brain tissue in vivo due to bloodbrain barrier disruption, limiting clinical utility
Looking ahead, in the realm of ARD, several innovative and forward-looking avenues for future research emerge
