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This study serves as a critical step forward for the application of TAT-CcSOD1 as a potential protective/therapeutic agent against oxidative stress-related conditions in the future

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GLRX has been implicated in the regulation of protein synthesis 12 , cellular proliferation 13 , apoptosis 14 , and inflammatory responses 15 , among others

Off-target detection To determine the site-specific cleavage of the CRISPRCas9 system in vivo, the potential off-target loci were searched using Cas-OFFinder ( The selected potential off-target sites were initially PCR-amplified and then subjected to a DNA sequencing assay