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Human clinical research remains early stage, with small pilot studies exploring its effects on exercise performance, insulin sensitivity, and metabolic biomarkers rather than obesity endpoints

Deficiency may cause fatigue, neurological symptoms, and cognitive changes, with treatment often improving symptoms when deficiency is present

This treatment may help: Support energy levels and reduce fatigue Aid metabolism and assist with weight management Promote red blood cell production and immune function Enhance focus, memory, and cognitive function B12 injections are ideal for individuals with low B12 levels, those following a plant-based diet, or anyone looking for a natural energy boost

Washington (DC): National Academies Press (US)

Additionally, methylated quinolines such as 5-amino-1-methylquinolinium have been identified as NNMT inhibitors through ligand-based in silico methods and biological evaluations 203