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The previous interactions contribute to the activation of the peripheral immune system and primes CNS microglia, creating a neuroinflammatory environment that aggravate behavioral deficits (Manda et al., 2012
Therefore, folate is critical for rapidly dividing cells, including erythroblasts (red blood cell precursors in the bone marrow) and developing foetal tissue

In co-culture assays including CAFs and cancer cells, tyrosine phosphorylation of EphA2 on CAFs was increased, which led to enhanced invasiveness of cancer cells [194, 195]
