foxo4-dri senolytic 2023 2024 regulates endothelial cell senescence via the P53 signaling pathway Senolytic therapeutics: An emerging treatment

11 3D organotypic culture (in vitro studies) An in vitro three-dimensional (3D) organotypic culture was employed to further investigate the mechanisms of treatments observed on cancer progression

Senescent Chondrocyte Removal & Chondrogenic Potential Restoration (PMC, 2021) FOXO4-DRI Removes Replication-Stress Senescent Chondrocytes in ACI Research Model A study published in PMC investigated FOXO4-DRI in the context of autologous chondrocyte implantation (ACI) a procedure in which in vitro chondrocyte expansion generates a senescent cell burden that adversely affects cartilage formation quality and quantity

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treatment with a zonulin antagonist, larazotide, ameliorated the disease symptoms by improving barrier function