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Finally, deferiprone, an iron chelator, was demonstrated to inhibit iron homeostasis imbalance and ferroptosis, and protect RGCs and visual function
Recent in vitro studies have demonstrated that a blockade of the GLT-1 transporter either by transport inhibitors or by an antisense approach resulted in a slow, selective loss of motor neurons, thus strengthening the case for a critical role for GLT-1 in the etiology of ALS [62,75]
30 , R1292R1297 (2020)
eLife 5 , e12813 (2016)
Some preclinical studies have shown promising results in animal models, suggesting potential benefits for neurodegenerative conditions
