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In view of the emerging molecular subtypes of colon cancer and their suggested therapeutic implications, should we now assign treatment strategies based on these subtypes

The MAT2A gene is located on chromosome 2p11.2 and is composed of 9 exons that encode a protein of 395 amino acids

Muscle aches occurred in 3.7-7.7% versus 1.6-2.2% on placebo

Sirtuins, particularly SIRT1 and SIRT3, protect cells from oxidative stress by increasing the activity of antioxidant enzymes, including superoxide dismutase 2 (SOD2) and CAT (127, 131, 132)

That decision is made in consultation, based on the individual patients labs, history, and goals