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Clin Colorectal Cancer 19(1):48-56.e2, 2020

324 In PD, some familial variants are linked to mutations in PRKN , which encodes an E3 ubiquitin ligase, and PD-associated -synuclein accumulation has also been shown to inhibit UPS activity (for a detailed discussion, see Lim & Tan (2007) 325 )

Reactive oxygen species Similar to many other tissues, the vascular wall is in a constant process of molecular oxidation and reduction

JaD, JG, LK, and BT participated in writing this manuscript

Some patients use maintenance protocols for ongoing digestive support
