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Examples include Wedel et al.s exploration of factors including sex, alcohol dose, exercise, and food (160) and more recent efforts by Zekan et al

Supports recovery after exercise, physical strain, or injury

In db/db mice, CK treatment increases secondary BAs, such as lithocholic acid (LCA) and deoxycholic acid (DCA) through changes in the gut microbiota, especially the Ruminococcaceae family, and up-regulation of cytochrome P450 family 7 subfamily B member 1 ( Cyp7b1 ) and cytochrome P450 family 27 subfamily A member 1 ( Cyp27a1 ) and down-regulation of cytochrome P450 family 8 subfamily B member 1 ( Cyp8b1 ), which changes BA biosynthesis from the classical pathway to the alternative pathway

Pairing Kisspeptin-10 with a reduced-dose SERM creates complementary mechanisms: kisspeptin stimulates GnRH release from above while the SERM blocks estrogen negative feedback from below