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Inhibition of ACMSD with compounds TES-991 and TES-1025 has been shown to increase NAD + levels in both cells and mice 235 (Fig
This essential coenzyme forms the foundation for healthy aging through its many roles in cellular metabolism, DNA repair, and signaling pathways

doi: 10.1038/s41430-018-0118-x

This dysregulation can cause estrogen production to drop as well
