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Under these conditions, characteristic patterns of iron accumulation precede or accompany neuronal degeneration, suggesting that iron-induced lipid peroxidation may be a critical upstream event driving pathological cascades

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BioDrugs 34(1):1126 Kapingidza AB, Kowal K, Chruszcz M (2020) Antigenantibody complexes

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NRF2 and cancer NRF2 is frequently mutated in many types of cancers, with the mutations clustered around the DLG (43 %) and ETGE (57 %) motifs, which are the two critical KEAP1 interaction domains [95]