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Both the SWI/SNF inhibitor AU-15330 and the mitochondrial complex I oxidative phosphorylation inhibitor IACS-010759 showed pronounced synergy with bi-steric mTORC1 inhibitors to cause cuproptotic cell death in RP/MRD cells, suggesting these combinations as a potential patient treatment strategy for rapalog resistance

Halestrap AP, McStay GP, Clarke SJ

Kombucha: review

Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S

More recently, machine learning models that combine metabolomic readouts with embryologic and imaging-derived variables have reported improved implantation prediction compared with single data streams, supporting late integration or stacked models under careful cross-validation and external replication [436]