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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

doi: 10.1161/01.res.86.12.1252

[DOI] [PubMed] [Google Scholar] 150.Bardag-Gorce F., Yuan Q.X., Li J., French B.A., Fang C., Ingelman-Sundberg M., French S.W

Regulated necrosis: The expanding network of non-apoptotic cell death pathways

Hagen,Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?Aging Cell, 2012
