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Wild-type IDH1 overexpression fully rescued the phenotype, demonstrating that the observations are not due to off-target effects (Extended Data Fig
2009 Sep 29;106(39):16799804
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In particular, xCT and mGluR2 downregulation at the hippocampal level correlates with depressive and low resilience phenotypes to stress [165], and the reduced expression of mGluR2 may provide insights into the virus-induced vulnerability to stress-related conditions [20, 168]
