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Otaguiri, E

2-HG is a metabolite that is structurally similar to -ketoglutarate, and the accumulation of 2-HG due to IDH mutations inhibits -ketoglutarate-dependent demethylases, which play a role in DNA and histone demethylation, thereby affecting epigenetic regulation (e.g., inhibition of DNA and histone demethylase, leading to global DNA hypermethylation), one-carbon metabolism methylase, which plays a role in DNA and histone demethylation, thereby affecting epigenetic regulation (e.g

Sekhar RV

To test their function, we expressed candidates in monoaminergic neurons in C