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M9a + sh EPAS1 cells attenuate inflammation by enhancing mitophagy under hypoxia To investigate the mechanism of Tibetan adaptation to hypoxia, RNA sequencing was performed on three cell lines (M7/8+shCTR, M9a+shCTR, M9a+sh EPAS1 )

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Validation of gene expression data by qRT-PCR To verify the reliability of RNA-seq data, we randomly selected 13 DEGs related to photosynthesis ( FtPinG0008168200.0 , FtPinG0008444600.01 , FtPinG0000127100.01 , and FtPinG0002658600.01 ) and carbon metabolism pathways ( FtPinG0003207000.01 and novel.1080 ) involved in chilling stress tolerance in Tartary buckwheat for qRT-PCR analysis (Fig

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*Correspondence: Chi Wang Ip, [email protected] This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers