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The choice of agent is influenced by individual disease activity, patient profile, and safety considerations [145]

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Primary antibodies were purchased from the following companies: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Beyotime, Shanghai, China), heme oxygenase-1 (HO-1), solute carrier family 7 member 11 (SLC7A11) and Hypoxia-inducible factor-1 (HIF-1) (Proteintech, Wuhan, China), NADPH-quinone oxidoreductase1 (NQO-1) (HuaBio, Hangzhou, China), glutathione peroxidase4 (GPX4), acyl-CoA synthetase long-chain family member4 (ACSL4) and Sirtuin4 (SIRT4) (abclonal, Wuhan, China), lymphocyte antigen 6 complex locus G6D (Ly6G) and myeloperoxidase (MPO) (Abcam, Shanghai, China), cluster of differentiation molecule 11b (CD11b) (Boster, Wuhan, China), 4-hydroxynoneral (4-HNE)(RD systems, Shanghai, China)

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