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Description
The literature on getting the molecule to the cellular level is thin
L.ZhangW.ZhangJ.LianL
(2022), who showed Nrf2 regulates GSH synthesis via HO-1/GPX4, and our findings extend this: chronic Nrf2 suppression in mid-late SAE disrupts GSH homeostasis (impairing synthesis/recycling) and diminishes GPX4-mediated anti-lipid peroxidation, promoting ferroptosis
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Kiuchi T, Sei H, Seno H, Sano A, Morita Y
