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Undoubtedly, the development of targeted drugs encounters numerous challenges

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With respect to the studied compounds, compound A (Ferrostatin) has been reported to show anti-ferroptotic activity inhibit neurotoxicity induced by glutamate in HT-22 mouse hippocampal cell culture [20]

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For example, some TAMs interact with regulatory T cells and tumor cells to establish an immunosuppressive TME, reinforcing the notion that macrophages do not neatly fit into M1 or M2 categories (133)

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Physiological synaptic activity and recognition memory require astroglial glutamine

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(j) current treatment with medications with known glutamatergic properties such as dextromethorphan, d-cyloserine, amantadine, memantine, lamotrigine, or riluzole

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