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ERK differentially regulates T h17and T regcell development and contributes to the pathogenesis of colitis

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Intracellular antioxidant defense involves cytosolic Cu,Zn-SOD ( SOD1 ) and the mitochondrial matrix Mn-SOD ( SOD2 ), which dismutases superoxide radical anion (O 2 ) into hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 )