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Description
It is a tripeptide composed of the amino acids glutamic acid, cysteine and glycine

Most interesting is the differential response to CB-839 across all three KP mouse models following the same treatment regimen

The hepatic thiobarbituric acid reactive substances (TBARS), nitrite, carbonyl content, and OH-1 expression increased
CYP2E1 is localized in liver mitochondria instead of the endoplasmic reticulum

Overall, these studies suggest that ERCP and biliary sphincterotomy is indicated (preferably within 24 h of admission) for patients with severe biliary pancreatitis with retained common bile duct stones and for those with cholangitis
