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doi: 10.3389/fmed.2023.1098047 Received 17 November 2022 Accepted 02 January 2023 Published 23 January 2023 Volume 10 - 2023 Edited by Manuel Pedro Pereira, Charit Universittsmedizin Berlin, Germany Reviewed by Jan Mauno Ehrchen, University of Mnster, Germany

In their report from 2003 Voedingsnormen: vitamine B6, foliumzuur en vitamine B12 the council joined expert commissions from the American Institute of Medicine and the Scientific Committee for Human Food from the European Union, who had already reported 3 years earlier that toxicity from high dose vitamin B12 poses no real danger

Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

Genetic variations in methionine synthase (MTHFR) and cobalamin metabolism genes can predispose individuals to poor B12 utilization, making biomarker context clinically essential before therapy initiation

Wakayama EJ, Dillwith JW, Howard RW, Blomquist GJ (1984)