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Quinone compounds are notorious redox cyclers, present in drugs such as doxorubicin, which is used to treat a host of human cancers

Similar to the substituents described for alkyl groups above, exemplary substituents for aryl and heteroaryl groups (as well as their divalent derivatives) are varied and are selected from, for example: halogen, OR, NRR, SR, SiRRR, OC(O)R, C(O)R, CO 2 R, C(O)NRR, OC(O)NRR, NRC(O)R, NRC(O)NRR, NRC(O)OR, NRC(NRRR)NR, NRC(NRR)NRS(O)R, S(O) 2 R, S(O) 2 NRR, NRSO 2 R, CN and NO 2 , R, N 3 , CH(Ph) 2 , fluoro(C 1-4 )alkoxo, and fluoro(C 1-4 )alkyl, in a number ranging from zero to the total number of open valences on aromatic ring system

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After intestinal absorption, SFN forms metabolites such as SFN-glutathione, SFN-cysteine, and SFN-N-acetylcysteine in plasma and tissues, which may contribute to its anti-inflammatory effects