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The lower intracellular levels of serine and glycine in cancer cells that we observed in vitro indicate a high turnover with increased consumption and usage of these amino acids in downstream biosynthetic pathways, which is supported by the enhanced SHMT2 expression in response to RT

10.3389/fncel.2022.841731 72 WangY.CaoP.AlshwmiM.JiangN.XiaoZ.JiangF.et al (2019)

A 2024 review recognized AOD-9604 among key peptides showing promise for cartilage regeneration in osteoarthritis, though the authors note that more research, particularly in human subjects, is needed to establish clinical efficacy

doi: 10.1038/nature13535
