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On the other hand, excessive VitE toxicity has been linked to headaches, weariness, dizziness, intestinal irritation, prolonged prothrombin time, and difficulty with the absorption of vitamins A and K

For instance, TYR staining was markedly reduced in the melanocytes of hair follicles with mild or moderate canities, despite strong TRP-1 expression in the same hair follicle (see supplementary figure 1)

Litchfield K, Reading JL, Lim EL, Xu H, Liu P, Al-Bakir M, et al

In section 2.9 of the ICH S7A, conditions under which studies may not be necessary (e.g., locally applied products) and considerations for biologics are described

This dose-tolerability relationship provides useful guidance for clinical protocol development