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Warnings Patients who have early Leber's disease (LHON) a hereditary disease that causes optic nerve atrophy have been found to suffer severe and swift optic atrophy when treated with vitamin B12

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Women with invasive lobular carcinoma had a poorer response to primary chemotherapy yet better overall survival

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Exceeding the RDA is not recommended, because the pregnancy category falls to a C level at such doses

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