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Mitochondrial Damage Mitochondria are the major cellular site of ROS production and damage to mitochondrial structure or function increases oxidative stress (Albers and Beal, 2000

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Whereas the other commonly used antidepressants for neuropathic pain (e.g., tricyclic antidepressants) are associated with a distinctive risk for QT prolongation, only a high TRZ dosage affects the QT interval [29]