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Downmodulation of the NRF2 pathway was also confirmed by RT-qPCR analyses of four known NRF2 transcriptional targets ( GCLM , GSR , NQO1 , and MGST1 ) in both Hs 578T and MDA-MB-231 TNBC cells, showing reduced expression of these genes upon Cyss deprivation (Fig
Glutathione levels decrease with age, making the body and the brain more vulnerable to oxidative damage
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