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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ

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Ozden and his colleagues reported that SIRT3 deacetylates the Pyruvate Dehydrogenase E1 Subunit Alpha 1 (PDHA1) subunit of pyruvate dehydrogenase complex (PDC) at the K321 position, thereby increasing its activity, which reverses the Warburg effect as glucose consumption and lactate production are reduced [83]

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