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2005 Oncology World Congress
doi: 10.23750/abm.v90i3-S.8160
For nGB, the presence of FDA-approved standard chemotherapy (TMZ) limits the application of new therapies and delays the approval of new drugs for nGB
However, pGSN interferes with this process by inducing apoptosis in M1 macrophages and reducing their production of NO and TNF, thereby inhibiting their anti-tumor function
More studies are needed to explore whether the GPX4-mediated activation of parthanatos is a widespread mechanism in other disease models, and how the lipid peroxidation involved in the regulation of parthanatos
