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However, these cell types are far fewer in number in the liver than hepatocytes, which represent 7080 % of liver and are responsible for first-pass metabolism
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Among its oxidation products there are the 8-hydroxy-2-deoxyguanosine (8-OHdG) and the 8-oxo-7,8-dihydroguanine (8-oxoGua) (Zhang et al., 2013)
