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Interestingly, it has been described that VDR expression can be modulated by vitamin D itself (40), thus demonstrating an involvement of both ligand and receptor downmodulation in AD

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and (3) the capacity to differentiate into osteogenic, chondrogenic, and adipogenic lineages under in vitro conditions

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Front Pharmacol 5:151 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds