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doi: 10.1001/JAMA.2013.4997 [DOI] [PubMed] [Google Scholar] 221.Kassoff A, Buehler J, Kassoff J, et al

If tiredness is caused by a confirmed vitamin B12 deficiency, many people report noticing changes within: A few days to one week some individuals feel improvement in energy levels relatively quickly

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One suggested explanation is that the PYY3-36 effect is critically modulated by the time of injection

The practical consequence is that dose frequency is governed by downstream signalling windows, not plasma kinetics